Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in...
Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner
About this item
Full title
Author / Creator
Eysert, Fanny , Coulon, Audrey , Boscher, Emmanuelle , Vreulx, Anaїs-Camille , Flaig, Amandine , Mendes, Tiago , Hughes, Sandrine , Grenier-Boley, Benjamin , Hanoulle, Xavier , Demiautte, Florie , Bauer, Charlotte , Marttinen, Mikael , Takalo, Mari , Amouyel, Philippe , Desai, Shruti , Pike, Ian , Hiltunen, Mikko , Chécler, Frédéric , Farinelli, Mélissa , Delay, Charlotte , Malmanche, Nicolas , Hébert, Sébastien S. , Dumont, Julie , Kilinc, Devrim , Lambert, Jean-Charles and Chapuis, Julien
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Although APP metabolism is being intensively investigated, a large fraction of its modulators is yet to be characterized. In this context, we combined two genome-wide high-content screenings to assess the functional impact of miRNAs and genes on APP metabolism and the signaling pathways involved. This approach highlighted the involvement of
FERM...
Alternative Titles
Full title
Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner
Authors, Artists and Contributors
Author / Creator
Coulon, Audrey
Boscher, Emmanuelle
Vreulx, Anaїs-Camille
Flaig, Amandine
Mendes, Tiago
Hughes, Sandrine
Grenier-Boley, Benjamin
Hanoulle, Xavier
Demiautte, Florie
Bauer, Charlotte
Marttinen, Mikael
Takalo, Mari
Amouyel, Philippe
Desai, Shruti
Pike, Ian
Hiltunen, Mikko
Chécler, Frédéric
Farinelli, Mélissa
Delay, Charlotte
Malmanche, Nicolas
Hébert, Sébastien S.
Dumont, Julie
Kilinc, Devrim
Lambert, Jean-Charles
Chapuis, Julien
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8758496
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8758496
Other Identifiers
ISSN
1359-4184
E-ISSN
1476-5578
DOI
10.1038/s41380-020-00926-w
