Differential Gene Expression Profiles between N-Terminal Domain and Ligand-Binding Domain Inhibitors...
Differential Gene Expression Profiles between N-Terminal Domain and Ligand-Binding Domain Inhibitors of Androgen Receptor Reveal Ralaniten Induction of Metallothionein by a Mechanism Dependent on MTF1
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Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Hormonal therapies for prostate cancer target the androgen receptor (AR) ligand-binding domain (LBD). Clinical development for inhibitors that bind to the N-terminal domain (NTD) of AR has yielded ralaniten and its analogues. Ralaniten acetate is well tolerated in patients at 3600 mgs/day. Clinical trials are ongoing with a second-generation analog...
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Full title
Differential Gene Expression Profiles between N-Terminal Domain and Ligand-Binding Domain Inhibitors of Androgen Receptor Reveal Ralaniten Induction of Metallothionein by a Mechanism Dependent on MTF1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8773799
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8773799
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ISSN
2072-6694
E-ISSN
2072-6694
DOI
10.3390/cancers14020386
