Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer’s di...
Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer’s disease mice
About this item
Full title
Author / Creator
Park, Min Hee , Park, Kang Ho , Choi, Byung Jo , Han, Wan Hui , Yoon, Hee Ji , Jung, Hye Yoon , Lee, Jihoon , Song, Im-Sook , Lim, Dong Yu , Choi, Min-Koo , Lee, Yang-Ha , Park, Cheol-Min , Wang, Ming , Jo, Jihoon , Kim, Hee-Jin , Kim, Seung Hyun , Schuchman, Edward H. , Jin, Hee Kyung and Bae, Jae-sung
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Alzheimer’s disease (AD) is characterized by complex, multifactorial neuropathology, suggesting that small molecules targeting multiple neuropathological factors are likely required to successfully impact clinical progression. Acid sphingomyelinase (ASM) activation has been recognized as an important contributor to these neuropathological features...
Alternative Titles
Full title
Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer’s disease mice
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8784098
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8784098
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2115082119
