Restoration of Nusinersen Levels Following Treatment Interruption in People With Spinal Muscular Atr...
Restoration of Nusinersen Levels Following Treatment Interruption in People With Spinal Muscular Atrophy: Simulations Based on a Population Pharmacokinetic Model
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Cham: Springer International Publishing
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Language
English
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Publisher
Cham: Springer International Publishing
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Background
Nusinersen is approved for the treatment of spinal muscular atrophy. The most common approved dosing regimen is four intrathecal loading doses of nusinersen 12 mg; the first three are administered at 14-day intervals followed by a fourth dose 30 days later, and then 12-mg maintenance doses are administered every 4 months thereafter. I...
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Full title
Restoration of Nusinersen Levels Following Treatment Interruption in People With Spinal Muscular Atrophy: Simulations Based on a Population Pharmacokinetic Model
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8790013
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8790013
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ISSN
1172-7047,1179-1934
E-ISSN
1179-1934
DOI
10.1007/s40263-022-00899-0
