Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human c...
Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Topoisomerases nick and reseal DNA to relieve torsional stress associated with transcription and replication and to resolve structures such as knots and catenanes. Stabilization of the yeast Top2 cleavage intermediates is mutagenic in yeast, but whether this extends to higher eukaryotes is less clear. Chemotherapeutic topoisomerase poisons also ele...
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Full title
Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8795545
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8795545
Other Identifiers
ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.2114024119
