Variant allele frequency in baseline circulating tumour DNA to measure tumour burden and to stratify...
Variant allele frequency in baseline circulating tumour DNA to measure tumour burden and to stratify outcomes in patients with RAS wild-type metastatic colorectal cancer: a translational objective of the Valentino study
About this item
Full title
Author / Creator
Manca, Paolo , Corallo, Salvatore , Lonardi, Sara , Fucà, Giovanni , Busico, Adele , Leone, Alberto Giovanni , Corti, Francesca , Antoniotti, Carlotta , Procaccio, Letizia , Smiroldo, Valeria , Ratti, Margherita , Murialdo, Roberto , Racca, Patrizia , Pagani, Filippo , Randon, Giovanni , Martinetti, Antonia , Sottotetti, Elisa , Prisciandaro, Michele , Ambrosini, Margherita , Raimondi, Alessandra , Morano, Federica and Pietrantonio, Filippo
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Introduction
In patients with metastatic colorectal cancer (mCRC), baseline circulating tumour DNA (ctDNA) variant allele fraction (VAF) might serve as a surrogate of disease burden and should be evaluated in comparison with CEA and RECIST-defined sum of target lesions.
Methods
In this pre-planned analysis of the VALENTINO trial, we includ...
Alternative Titles
Full title
Variant allele frequency in baseline circulating tumour DNA to measure tumour burden and to stratify outcomes in patients with RAS wild-type metastatic colorectal cancer: a translational objective of the Valentino study
Authors, Artists and Contributors
Author / Creator
Corallo, Salvatore
Lonardi, Sara
Fucà, Giovanni
Busico, Adele
Leone, Alberto Giovanni
Corti, Francesca
Antoniotti, Carlotta
Procaccio, Letizia
Smiroldo, Valeria
Ratti, Margherita
Murialdo, Roberto
Racca, Patrizia
Pagani, Filippo
Randon, Giovanni
Martinetti, Antonia
Sottotetti, Elisa
Prisciandaro, Michele
Ambrosini, Margherita
Raimondi, Alessandra
Morano, Federica
Pietrantonio, Filippo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8810873
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8810873
Other Identifiers
ISSN
0007-0920,1532-1827
E-ISSN
1532-1827
DOI
10.1038/s41416-021-01591-8
