CRISPR Editing Enables Consequential Tag-Activated MicroRNA-Mediated Endogene Deactivation
CRISPR Editing Enables Consequential Tag-Activated MicroRNA-Mediated Endogene Deactivation
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Molecular therapies and functional studies greatly benefit from spatial and temporal precision of genetic intervention. We therefore conceived and explored tag-activated microRNA (miRNA)-mediated endogene deactivation (TAMED) as a research tool and potential lineage-specific therapy. For proof of principle, we aimed to deactivate γ-globin repressor...
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Full title
CRISPR Editing Enables Consequential Tag-Activated MicroRNA-Mediated Endogene Deactivation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8834719
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8834719
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ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms23031082
