Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle primin...
Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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How can exactly six SNARE complexes be assembled under each synaptic vesicle? Here we report cryo-EM crystal structures of the core domain of Munc13, the key chaperone that initiates SNAREpin assembly. The functional core of Munc13, consisting of C1–C2B–MUN–C2C (Munc13C) spontaneously crystallizes between phosphatidylserine-rich bilayers in two dis...
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Full title
Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8851502
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8851502
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2121259119
