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Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver

Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8851562

Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver

About this item

Full title

Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2022-02, Vol.119 (7), p.1-11

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

The nuclear receptors liver X receptor (LXR) α and β play crucial roles in hepatic metabolism. Many genes induced in response to pharmacologic LXR agonism have been defined; however, the transcriptional consequences of loss of LXR binding to its genomic targets are less well characterized. Here, we addressed how deletion of both LXRα and LXRβ from...

Alternative Titles

Full title

Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8851562

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8851562

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.2122683119

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