Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Many cancers have an unusual dependence on glutamine. However, most previous studies have focused on the contribution of glutamine to metabolic building blocks and the energy supply. Here, we report that cancer cells with aberrant expression of glutamate decarboxylase 1 (GAD1) rewire glutamine metabolism for the synthesis of γ-aminobutyric acid (GA...
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Full title
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8852304
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8852304
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-021-00820-9
