Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-r...
Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial
About this item
Full title
Author / Creator
Hagel, Stefan , Bach, Friedhelm , Brenner, Thorsten , Bracht, Hendrik , Brinkmann, Alexander , Annecke, Thorsten , Hohn, Andreas , Weigand, Markus , Michels, Guido , Kluge, Stefan , Nierhaus, Axel , Jarczak, Dominik , König, Christina , Weismann, Dirk , Frey, Otto , Witzke, Dominic , Müller, Carsten , Bauer, Michael , Kiehntopf, Michael , Neugebauer, Sophie , Lehmann, Thomas , Roberts, Jason A. , Pletz, Mathias W. , the TARGET Trial Investigators and TARGET Trial Investigators
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Purpose
Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves outcomes.
Methods
Randomized, multicenter, controlled trial from January 2017 to December 2019. Adult patients (
n
= 254) with sepsis or septic shock were...
Alternative Titles
Full title
Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial
Authors, Artists and Contributors
Author / Creator
Bach, Friedhelm
Brenner, Thorsten
Bracht, Hendrik
Brinkmann, Alexander
Annecke, Thorsten
Hohn, Andreas
Weigand, Markus
Michels, Guido
Kluge, Stefan
Nierhaus, Axel
Jarczak, Dominik
König, Christina
Weismann, Dirk
Frey, Otto
Witzke, Dominic
Müller, Carsten
Bauer, Michael
Kiehntopf, Michael
Neugebauer, Sophie
Lehmann, Thomas
Roberts, Jason A.
Pletz, Mathias W.
the TARGET Trial Investigators
TARGET Trial Investigators
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8866359
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8866359
Other Identifiers
ISSN
0342-4642
E-ISSN
1432-1238
DOI
10.1007/s00134-021-06609-6
