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ArticlesPeer ReviewedFull Text
Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza
Author / Creator:Brehm, Thomas Theo ; van der Meirschen, Marc ; Hennigs, Annette ; Roedl, Kevin ; Jarczak, Dominik ; Wichmann, Dominic ; Frings, Daniel ; Nierhaus, Axel ; Oqueka, Tim ; Fiedler, Walter ; Christopeit, Maximilian ; Kraef, Christian ; Schultze, Alexander ; Lütgehetmann, Marc ; Addo, Marylyn M ; Schmiedel, Stefan ; Kluge, Stefan ; Schulze zur Wiesch, Julian
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-03, Vol.11 (1), p.5803-5803, Article 5803
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Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial
Author / Creator:Hagel, Stefan ; Bach, Friedhelm ; Brenner, Thorsten ; Bracht, Hendrik ; Brinkmann, Alexander ; Annecke, Thorsten ; Hohn, Andreas ; Weigand, Markus ; Michels, Guido ; Kluge, Stefan ; Nierhaus, Axel ; Jarczak, Dominik ; König, Christina ; Weismann, Dirk ; Frey, Otto ; Witzke, Dominic ; Müller, Carsten ; Bauer, Michael ; Kiehntopf, Michael ; Neugebauer, Sophie ; Lehmann, Thomas ; Roberts, Jason A. ; Pletz, Mathias W.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Intensive care medicine, 2022-03, Vol.48 (3), p.311-321
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Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression?
Author / Creator:Winkler, Martin Sebastian ; Rissiek, Anne ; Priefler, Marion ; Schwedhelm, Edzard ; Robbe, Linda ; Bauer, Antonia ; Zahrte, Corinne ; Zoellner, Christian ; Kluge, Stefan ; Nierhaus, Axel
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-08, Vol.12 (8), p.e0182427-e0182427
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Extracorporeal cytokine elimination as rescue therapy in refractory septic shock: a prospective single-center study
Author / Creator:Friesecke, Sigrun ; Stecher, Stephanie-Susanne ; Gross, Stefan ; Felix, Stephan B. ; Nierhaus, Axel
Publisher:Tokyo: Springer Japan
Journal title:Journal of artificial organs, 2017-09, Vol.20 (3), p.252-259
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The use of mid-regional proadrenomedullin to identify disease severity and treatment response to sepsis - a secondary analysis of a large randomised controlled trial
Author / Creator:Elke, Gunnar ; Bloos, Frank ; Wilson, Darius Cameron ; Brunkhorst, Frank Martin ; Briegel, Josef ; Reinhart, Konrad ; Loeffler, Markus ; Kluge, Stefan ; Nierhaus, Axel ; Jaschinski, Ulrich ; Moerer, Onnen ; Weyland, Andreas ; Meybohm, Patrick
Publisher:England: BioMed Central Ltd
Journal title:Critical care (London, England), 2018-03, Vol.22 (1), p.79-79, Article 79
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Decreased serum concentrations of sphingosine-1-phosphate in sepsis
Author / Creator:Winkler, Martin Sebastian ; Nierhaus, Axel ; Holzmann, Maximilian ; Mudersbach, Eileen ; Bauer, Antonia ; Robbe, Linda ; Zahrte, Corinne ; Geffken, Maria ; Peine, Sven ; Schwedhelm, Edzard ; Daum, Guenter ; Kluge, Stefan ; Zoellner, Christian
Publisher:England: BioMed Central Ltd
Journal title:Critical care (London, England), 2015-10, Vol.19 (1), p.372, Article 372
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Best-practice IgM- and IgA-enriched immunoglobulin use in patients with sepsis
Author / Creator:Nierhaus, Axel ; Berlot, Giorgio ; Kindgen-Milles, Detlef ; Müller, Eckhard ; Girardis, Massimo
Publisher:Cham: Springer International Publishing
Journal title:Annals of intensive care, 2020-10, Vol.10 (1), p.132-132, Article 132
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Symmetrical (SDMA) and asymmetrical dimethylarginine (ADMA) in sepsis: high plasma levels as combined risk markers for sepsis survival
Author / Creator:Winkler, Martin Sebastian ; Nierhaus, Axel ; Rösler, Gilbert ; Lezius, Susanne ; Harlandt, Olaf ; Schwedhelm, Edzard ; Böger, Rainer H. ; Kluge, Stefan
Publisher:England: BioMed Central
Journal title:Critical care (London, England), 2018-09, Vol.22 (1), p.216-10, Article 216
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Markers of nitric oxide are associated with sepsis severity: an observational study
Author / Creator:Winkler, Martin Sebastian ; Kluge, Stefan ; Holzmann, Maximilian ; Moritz, Eileen ; Robbe, Linda ; Bauer, Antonia ; Zahrte, Corinne ; Priefler, Marion ; Schwedhelm, Edzard ; Böger, Rainer H. ; Goetz, Alwin E. ; Nierhaus, Axel ; Zoellner, Christian
Publisher:England: BioMed Central Ltd
Journal title:Critical care (London, England), 2017-07, Vol.21 (1), p.189-9, Article 189
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Persistent mortality in critical COVID-19 ICU cases from wild-type to delta variant: A descriptive cohort study
Author / Creator:Palmowski, Lars ; Hagedorn, André ; Witowski, Andrea ; Haberl, Helge ; Kraft, Felix ; Achtzehn, Ute ; Kindgen-Milles, Detlef ; Zacharowski, Kai ; Nierhaus, Axel ; Dietrich, Maximilian ; Mirakaj, Valbona ; Koch, Thea ; Meybohm, Patrick ; Adamzik, Michael ; Bergmann, Lars ; Rahmel, Tim
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-03, Vol.15 (1), p.10191-10, Article 10191
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Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?
Author / Creator:Roedl, Kevin ; Jarczak, Dominik ; Drolz, Andreas ; Wichmann, Dominic ; Boenisch, Olaf ; de Heer, Geraldine ; Burdelski, Christoph ; Frings, Daniel ; Sensen, Barbara ; Nierhaus, Axel ; Lütgehetmann, Marc ; Kluge, Stefan ; Fuhrmann, Valentin
Publisher:Cham: Springer International Publishing
Journal title:Annals of intensive care, 2021-03, Vol.11 (1), p.44-44, Article 44
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Pharmacokinetics of meropenem in septic patients on sustained low-efficiency dialysis: a population pharmacokinetic study
Author / Creator:Braune, Stephan ; König, Christina ; Roberts, Jason A. ; Nierhaus, Axel ; Steinmetz, Oliver ; Baehr, Michael ; Kluge, Stefan ; Langebrake, Claudia
Publisher:England: BioMed Central Ltd
Journal title:Critical care (London, England), 2018-01, Vol.22 (1), p.25-25, Article 25
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Cerebrovascular autoregulation and arterial carbon dioxide in patients with acute respiratory distress syndrome: a prospective observational cohort study
Author / Creator:Kahl, Ursula ; Yu, Yuanyuan ; Nierhaus, Axel ; Frings, Daniel ; Sensen, Barbara ; Daubmann, Anne ; Kluge, Stefan ; Fischer, Marlene
Publisher:Cham: Springer International Publishing
Journal title:Annals of intensive care, 2021-03, Vol.11 (1), p.47-47, Article 47
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High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study
Author / Creator:Schroeder, Maria ; Schaumburg, Berfin ; Mueller, Zacharias ; Parplys, Ann ; Jarczak, Dominik ; Roedl, Kevin ; Nierhaus, Axel ; de Heer, Geraldine ; Grensemann, Joern ; Schneider, Bettina ; Stoll, Fabian ; Bai, Tian ; Jacobsen, Henning ; Zickler, Martin ; Stanelle-Bertram, Stephanie ; Klaetschke, Kristin ; Renné, Thomas ; Meinhardt, Andreas ; Aberle, Jens ; Hiller, Jens ; Peine, Sven ; Kreienbrock, Lothar ; Klingel, Karin ; Kluge, Stefan ; Gabriel, Guelsah
Publisher:London: Taylor & Francis
Journal title:Emerging microbes & infections, 2021-01, Vol.10 (1), p.1807-1818
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ArticlesPeer ReviewedFull Text
Loss of sphingosine 1-phosphate (S1P) in septic shock is predominantly caused by decreased levels of high-density lipoproteins (HDL)
Author / Creator:Winkler, Martin Sebastian ; Märtz, Konstantin B. ; Nierhaus, Axel ; Daum, Günter ; Schwedhelm, Edzard ; Kluge, Stefan ; Gräler, Markus H.
Publisher:England: BioMed Central Ltd
Journal title:Journal of intensive care, 2019-04, Vol.7 (1), p.23-9, Article 23
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Intravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study
Author / Creator:Rahmel, Tim ; Kraft, Felix ; Haberl, Helge ; Achtzehn, Ute ; Brandenburger, Timo ; Neb, Holger ; Jarczak, Dominik ; Dietrich, Maximilian ; Magunia, Harry ; Zimmer, Frieda ; Basten, Jale ; Landgraf, Claudia ; Koch, Thea ; Zacharowski, Kai ; Weigand, Markus A. ; Rosenberger, Peter ; Ullrich, Roman ; Meybohm, Patrick ; Nierhaus, Axel ; Kindgen-Milles, Detlef ; Timmesfeld, Nina ; Adamzik, Michael
Publisher:London: BioMed Central Ltd
Journal title:Critical care (London, England), 2022-07, Vol.26 (1), p.1-204, Article 204
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Predicting the requirement for renal replacement therapy in intensive care patients with sepsis
Author / Creator:Nierhaus, Axel ; Bloos, Frank ; Wilson, Darius Cameron ; Elke, Gunnar ; Meybohm, Patrick
Publisher:England: BioMed Central Ltd
Journal title:Critical care (London, England), 2018-08, Vol.22 (1), p.201-201, Article 201
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Revisiting the white blood cell count: immature granulocytes count as a diagnostic marker to discriminate between SIRS and sepsis - a prospective, observational study
Author / Creator:Nierhaus, Axel ; Klatte, Stefanie ; Linssen, Jo ; Eismann, Nina M ; Wichmann, Dominic ; Hedke, Jörg ; Braune, Stephan A ; Kluge, Stefan
Publisher:England: BioMed Central Ltd
Journal title:BMC immunology, 2013-02, Vol.14 (1), p.8-8, Article 8
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Impaired Degradation of Neutrophil Extracellular Traps: A Possible Severity Factor of Elderly Male COVID-19 Patients
Author / Creator:de Buhr, Nicole ; Parplys, Ann Christin ; Schroeder, Maria ; Henneck, Timo ; Schaumburg, Berfin ; Stanelle-Bertram, Stephanie ; Jarczak, Dominik ; Nierhaus, Axel ; Hiller, Jens ; Peine, Sven ; Kluge, Stefan ; Klingel, Karin ; Gabriel, Gülsah ; von Köckritz-Blickwede, Maren
Publisher:Basel, Switzerland: S. Karger AG
Journal title:Journal of innate immunity, 2022-01, Vol.14 (5), p.461-476
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Correction to: Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial
Author / Creator:Hagel, Stefan ; Bach, Friedhelm ; Brenner, Thorsten ; Bracht, Hendrik ; Brinkmann, Alexander ; Annecke, Thorsten ; Hohn, Andreas ; Weigand, Markus Alexander ; Michels, Guido ; Kluge, Stefan ; Nierhaus, Axel ; Jarczak, Dominik ; König, Christina ; Weismann, Dirk ; Frey, Otto ; Witzke, Dominic ; Müller, Carsten ; Bauer, Michael ; Kiehntopf, Michael ; Neugebauer, Sophie ; Lehmann, Thomas ; Roberts, Jason A. ; Pletz, Mathias W.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Intensive care medicine, 2022-05, Vol.48 (5), p.646-647
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Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza

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Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial

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Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression?

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Extracorporeal cytokine elimination as rescue therapy in refractory septic shock: a prospective single-center study

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The use of mid-regional proadrenomedullin to identify disease severity and treatment response to sepsis - a secondary analysis of a large randomised controlled trial

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Decreased serum concentrations of sphingosine-1-phosphate in sepsis

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Best-practice IgM- and IgA-enriched immunoglobulin use in patients with sepsis

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Symmetrical (SDMA) and asymmetrical dimethylarginine (ADMA) in sepsis: high plasma levels as combined risk markers for sepsis survival

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Markers of nitric oxide are associated with sepsis severity: an observational study

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Persistent mortality in critical COVID-19 ICU cases from wild-type to delta variant: A descriptive cohort study

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Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?

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Pharmacokinetics of meropenem in septic patients on sustained low-efficiency dialysis: a population pharmacokinetic study

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Cerebrovascular autoregulation and arterial carbon dioxide in patients with acute respiratory distress syndrome: a prospective observational cohort study

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High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study

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Loss of sphingosine 1-phosphate (S1P) in septic shock is predominantly caused by decreased levels of high-density lipoproteins (HDL)

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Intravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study

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Predicting the requirement for renal replacement therapy in intensive care patients with sepsis

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Revisiting the white blood cell count: immature granulocytes count as a diagnostic marker to discriminate between SIRS and sepsis - a prospective, observational study

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Impaired Degradation of Neutrophil Extracellular Traps: A Possible Severity Factor of Elderly Male COVID-19 Patients

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Correction to: Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial

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