The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
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Author / Creator
Domizio, Jeremy Di , Gulen, Muhammet F. , Saidoune, Fanny , Thacker, Vivek V. , Yatim, Ahmad , Sharma, Kunal , Nass, Théo , Guenova, Emmanuella , Schaller, Martin , Conrad, Curdin , Goepfert, Christine , de Leval, Laurence , Garnier, Christophe von , Berezowska, Sabina , Dubois, Anaëlle , Gilliet, Michel and Ablasser, Andrea
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung pathology and extrapulmonary complications
1
,
2
. Type I interferons (IFNs) have an essential role in the pathogenesis of COVID-19 (refs
3
–
5
). Although rapid induction of type I IFNs limits virus propagation, a sustained increase in the lev...
Alternative Titles
Full title
The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8891013
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8891013
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04421-w
