Nanobodies as allosteric modulators of Parkinson’s disease–associated LRRK2
Nanobodies as allosteric modulators of Parkinson’s disease–associated LRRK2
About this item
Full title
Author / Creator
Singh, Ranjan K. , Soliman, Ahmed , Guaitoli, Giambattista , Störmer, Eliza , von Zweydorf, Felix , Dal Maso, Thomas , Oun, Asmaa , Van Rillaer, Laura , Schmidt, Sven H. , Chatterjee, Deep , David, Joshua A. , Pardon, Els , Schwartz, Thomas U. , Knapp, Stefan , Kennedy, Eileen J. , Steyaert, Jan , Herberg, Friedrich W. , Kortholt, Arjan , Gloeckner, Christian Johannes and Versées, Wim
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) are a leading cause of the inherited form of Parkinson’s disease (PD), while LRRK2 overactivation is also associated with the more common idiopathic form of PD. LRRK2 is a large multidomain protein, including a GTPase as well as a Ser/Thr protein kinase domain. Common, disease-ca...
Alternative Titles
Full title
Nanobodies as allosteric modulators of Parkinson’s disease–associated LRRK2
Authors, Artists and Contributors
Author / Creator
Soliman, Ahmed
Guaitoli, Giambattista
Störmer, Eliza
von Zweydorf, Felix
Dal Maso, Thomas
Oun, Asmaa
Van Rillaer, Laura
Schmidt, Sven H.
Chatterjee, Deep
David, Joshua A.
Pardon, Els
Schwartz, Thomas U.
Knapp, Stefan
Kennedy, Eileen J.
Steyaert, Jan
Herberg, Friedrich W.
Kortholt, Arjan
Gloeckner, Christian Johannes
Versées, Wim
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8892280
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8892280
Other Identifiers
ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.2112712119
