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ArticlesPeer ReviewedFull Text
LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains
Author / Creator:Weng, Jui-Hung ; Aoto, Phillip C ; Lorenz, Robin ; Wu, Jian ; Schmidt, Sven H ; Manschwetus, Jascha T ; Kaila-Sharma, Pallavi ; Silletti, Steve ; Mathea, Sebastian ; Chatterjee, Deep ; Knapp, Stefan ; Herberg, Friedrich W ; Taylor, Susan S
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2022-02, Vol.20 (2), p.e3001427-e3001427
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ArticlesPeer ReviewedFull Text
Microtubule-Associated Serine/Threonine (MAST) Kinases in Development and Disease
Author / Creator:Rumpf, Marie ; Pautz, Sabine ; Drebes, Benedikt ; Herberg, Friedrich W ; Müller, Hans-Arno J
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2023-07, Vol.24 (15), p.11913
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Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3
Author / Creator:Muda, Kathrin ; Bertinetti, Daniela ; Gesellchen, Frank ; Hermann, Jennifer Sarah ; von Zweydorf, Felix ; Geerlof, Arie ; Jacob, Anette ; Ueffing, Marius ; Gloeckner, Christian Johannes ; Herberg, Friedrich W
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-01, Vol.111 (1), p.E34-E43
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ArticlesPeer ReviewedFull Text
Nanobodies as allosteric modulators of Parkinson’s disease–associated LRRK2
Author / Creator:Singh, Ranjan K. ; Soliman, Ahmed ; Guaitoli, Giambattista ; Störmer, Eliza ; von Zweydorf, Felix ; Dal Maso, Thomas ; Oun, Asmaa ; Van Rillaer, Laura ; Schmidt, Sven H. ; Chatterjee, Deep ; David, Joshua A. ; Pardon, Els ; Schwartz, Thomas U. ; Knapp, Stefan ; Kennedy, Eileen J. ; Steyaert, Jan ; Herberg, Friedrich W. ; Kortholt, Arjan ; Gloeckner, Christian Johannes ; Versées, Wim
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2022-03, Vol.119 (9), p.1-12
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ArticlesPeer ReviewedFull Text
Correction: LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains
Author / Creator:Weng, Jui-Hung ; Aoto, Phillip C ; Lorenz, Robin ; Wu, Jian ; Schmidt, Sven H ; Manschwetus, Jascha T ; Kaila-Sharma, Pallavi ; Silletti, Steve ; Torres-Paris, Constanza ; Mathea, Sebastian ; Chatterjee, Deep ; Knapp, Stefan ; Herberg, Friedrich W ; Taylor, Susan S
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2025-02, Vol.23 (2), p.e3003017
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ArticlesPeer ReviewedFull Text
Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2
Author / Creator:Manschwetus, Jascha T ; Wallbott, Maximilian ; Fachinger, Alexandra ; Obergruber, Claudia ; Pautz, Sabine ; Bertinetti, Daniela ; Schmidt, Sven H ; Herberg, Friedrich W
Publisher:Switzerland: Frontiers Research Foundation
Journal title:Frontiers in neuroscience, 2020-04, Vol.14, p.302-302
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ArticlesPeer ReviewedFull Text
Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries
Author / Creator:Kummer, Lutz ; Parizek, Petra ; Rube, Peter ; Millgramm, Bastian ; Prinz, Anke ; Mittl, Peer R. E ; Kaufholz, Melanie ; Zimmermann, Bastian ; Herberg, Friedrich W ; Plückthun, Andreas
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-08, Vol.109 (34), p.E2248-E2257
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ArticlesPeer ReviewedFull Text
Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca2+ channel may modulate its β-adrenergic regulation
Author / Creator:Oz, Shimrit ; Keren-Raifman, Tal ; Sharon, Tom ; Subramaniam, Suraj ; Pallien, Tamara ; Katz, Moshe ; Tsemakhovich, Vladimir ; Sholokh, Anastasiia ; Watad, Baraa ; Tripathy, Debi Ranjan ; Sasson, Giorgia ; Chomsky-Hecht, Orna ; Vysochek, Leonid ; Schulz-Christian, Maike ; Fecher-Trost, Claudia ; Zühlke, Kerstin ; Bertinetti, Daniela ; Herberg, Friedrich W. ; Flockerzi, Veit ; Hirsch, Joel A. ; Klussmann, Enno ; Weiss, Sharon ; Dascal, Nathan
Publisher:London: BioMed Central
Journal title:BMC biology, 2024-11, Vol.22 (1), p.1-22, Article 276
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ArticlesPeer ReviewedFull Text
Structure-guided design of selective Epac1 and Epac2 agonists
Author / Creator:Schwede, Frank ; Bertinetti, Daniela ; Langerijs, Carianne N ; Hadders, Michael A ; Wienk, Hans ; Ellenbroek, Johanne H ; de Koning, Eelco J P ; Bos, Johannes L ; Herberg, Friedrich W ; Genieser, Hans-Gottfried ; Janssen, Richard A J ; Rehmann, Holger
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2015-01, Vol.13 (1), p.e1002038-e1002038
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ArticlesPeer ReviewedFull Text
Pigment-dispersing factor neuropeptides act as multifunctional hormones and modulators in tardigrades
Author / Creator:Dutta, Soumi ; Hering, Lars ; Grollmann, Milena M ; Metzendorf, Niklas ; Gross, Vladimir ; Arakawa, Kazuharu ; Neupert, Susanne ; Stengl, Monika ; Herberg, Friedrich W ; Mayer, Georg
Publisher:England: The Royal Society
Journal title:Open biology, 2025-03, Vol.15 (3), p.240242
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ArticlesPeer ReviewedFull Text
A novel c-di-GMP binding domain in glycosyltransferase BgsA is responsible for the synthesis of a mixed-linkage β-glucan
Author / Creator:Pérez-Mendoza, Daniel ; Bertinetti, Daniela ; Lorenz, Robin ; Gallegos, María-Trinidad ; Herberg, Friedrich W. ; Sanjuán, Juan
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-08, Vol.7 (1), p.8997-11, Article 8997
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ArticlesPeer ReviewedFull Text
A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A
Author / Creator:Manschwetus, Jascha T ; Bendzunas, George N ; Limaye, Ameya J ; Knape, Matthias J ; Herberg, Friedrich W ; Kennedy, Eileen J
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2019-04, Vol.24 (8), p.1567
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ArticlesPeer ReviewedFull Text
An auto-inhibited state of protein kinase G and implications for selective activation
Author / Creator:Sharma, Rajesh ; Kim, Jeong Joo ; Qin, Liying ; Henning, Philipp ; Akimoto, Madoka ; VanSchouwen, Bryan ; Kaur, Gundeep ; Sankaran, Banumathi ; MacKenzie, Kevin R ; Melacini, Giuseppe ; Casteel, Darren E ; Herberg, Friedrich W ; Kim, Choel
Publisher:United States: eLife Sciences Publications, Ltd
Journal title:eLife, 2022-08, Vol.11
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ArticlesPeer ReviewedFull Text
Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme
Author / Creator:Zhang, Ping ; Knape, Matthias J ; Ahuja, Lalima G ; Keshwani, Malik M ; King, Charles C ; Sastri, Mira ; Herberg, Friedrich W ; Taylor, Susan S
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2015-07, Vol.13 (7), p.e1002192-e1002192
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ArticlesPeer ReviewedFull Text
Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery
Author / Creator:Taylor, Susan S. ; Kaila-Sharma, Pallavi ; Weng, Jui-Hung ; Aoto, Phillip ; Schmidt, Sven H. ; Knapp, Stefan ; Mathea, Sebastian ; Herberg, Friedrich W.
Publisher:Lausanne: Frontiers Research Foundation
Journal title:Frontiers in molecular neuroscience, 2020-10, Vol.13, p.538219-538219
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ArticlesPeer ReviewedFull Text
Regulation of Cardiac PKA Signaling by cAMP and Oxidants
Author / Creator:Cuello, Friederike ; Herberg, Friedrich W ; Stathopoulou, Konstantina ; Henning, Philipp ; Diering, Simon
Publisher:Switzerland: MDPI AG
Journal title:Antioxidants, 2021-04, Vol.10 (5), p.663
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ArticlesPeer ReviewedFull Text
RedOx regulation of LRRK2 kinase activity by active site cysteines
Author / Creator:Trilling, Chiara R. ; Weng, Jui-Hung ; Sharma, Pallavi Kaila ; Nolte, Viktoria ; Wu, Jian ; Ma, Wen ; Boassa, Daniela ; Taylor, Susan S. ; Herberg, Friedrich W.
Publisher:London: Nature Publishing Group UK
Journal title:NPJ Parkinson's Disease, 2024-04, Vol.10 (1), p.75-75, Article 75
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Crystal structures of the carboxyl cGMP binding domain of the Plasmodium falciparum cGMP-dependent protein kinase reveal a novel capping triad crucial for merozoite egress
Author / Creator:Kim, Jeong Joo ; Flueck, Christian ; Franz, Eugen ; Sanabria-Figueroa, Eduardo ; Thompson, Eloise ; Lorenz, Robin ; Bertinetti, Daniela ; Baker, David A ; Herberg, Friedrich W ; Kim, Choel
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2015-02, Vol.11 (2), p.e1004639-e1004639
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ArticlesPeer ReviewedFull Text
Transient Receptor Potential Vanilloid 1 Signaling Is Independent on Protein Kinase A Phosphorylation of Ankyrin-Rich Membrane Spanning Protein
Author / Creator:Pellegrino, Antonio ; Mükusch, Sandra ; Seitz, Viola ; Stein, Christoph ; Herberg, Friedrich W ; Seitz, Harald
Publisher:Switzerland: MDPI AG
Journal title:Medical sciences (Basel), 2022-11, Vol.10 (4), p.63
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ArticlesPeer ReviewedFull Text
chicken leukocyte receptor complex encodes a primordial, activating, high-affinity IgY Fc receptor
Author / Creator:Viertlboeck, Birgit C ; Schweinsberg, Sonja ; Hanczaruk, Matthias A ; Schmitt, Ramona ; Du Pasquier, Louis ; Herberg, Friedrich W ; Göbel, Thomas W
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2007-07, Vol.104 (28), p.11718-11723
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Showing 1 to 20 of 54 results

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LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains

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Microtubule-Associated Serine/Threonine (MAST) Kinases in Development and Disease

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Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3

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Nanobodies as allosteric modulators of Parkinson’s disease–associated LRRK2

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Correction: LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains

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Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2

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Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries

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Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca2+ channel may modulate its β-adrenergic regulation

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Structure-guided design of selective Epac1 and Epac2 agonists

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Pigment-dispersing factor neuropeptides act as multifunctional hormones and modulators in tardigrades

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A novel c-di-GMP binding domain in glycosyltransferase BgsA is responsible for the synthesis of a mixed-linkage β-glucan

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A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A

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An auto-inhibited state of protein kinase G and implications for selective activation

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Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme

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Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery

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Regulation of Cardiac PKA Signaling by cAMP and Oxidants

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RedOx regulation of LRRK2 kinase activity by active site cysteines

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Crystal structures of the carboxyl cGMP binding domain of the Plasmodium falciparum cGMP-dependent protein kinase reveal a novel capping triad crucial for merozoite egress

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Transient Receptor Potential Vanilloid 1 Signaling Is Independent on Protein Kinase A Phosphorylation of Ankyrin-Rich Membrane Spanning Protein

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chicken leukocyte receptor complex encodes a primordial, activating, high-affinity IgY Fc receptor

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