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The C-terminal actin-binding domain of talin forms an asymmetric catch bond with F-actin

The C-terminal actin-binding domain of talin forms an asymmetric catch bond with F-actin

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8915792

The C-terminal actin-binding domain of talin forms an asymmetric catch bond with F-actin

About this item

Full title

The C-terminal actin-binding domain of talin forms an asymmetric catch bond with F-actin

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2022-03, Vol.119 (10), p.1-7

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Focal adhesions (FAs) are large, integrin-based protein complexes that link cells to the extracellular matrix (ECM). FAs form only when and where they are necessary to transmit force between the cellular cytoskeleton and the ECM, but how this occurs remains poorly understood. Talin is a 270-kDa adaptor protein that links integrins to filamentous (F...

Alternative Titles

Full title

The C-terminal actin-binding domain of talin forms an asymmetric catch bond with F-actin

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8915792

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8915792

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.2109329119

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