Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of rapamycin to enhance allogene...
Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of rapamycin to enhance allogeneic islet graft viability
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Standard oral rapamycin (that is, Rapamune) administration is plagued by poor bioavailability and broad biodistribution. Thus, this pleotropic mammalian target of rapamycin (mTOR) inhibitor has a narrow therapeutic window and numerous side effects and provides inadequate protection to transplanted cells and tissues. Furthermore, the hydrophobicity...
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Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of rapamycin to enhance allogeneic islet graft viability
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8934301
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8934301
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ISSN
1748-3387
E-ISSN
1748-3395
DOI
10.1038/s41565-021-01048-2
