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Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8942854

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Activated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme
1

4
. Here we show that despite tryptophan depletion, in-frame protein synthesis continues across tryptophan codons. We identified tryptophan-to-phenylalanine codon reassignment (W>F)...

Alternative Titles

Full title

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8942854

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8942854

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-022-04499-2

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