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Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

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Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8942854

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

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London: Nature Publishing Group UK

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Contents

Activated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme
1
–
4
. Here we show that despite tryptophan depletion, in-frame protein synthesis continues across tryptophan codons. We identified tryptophan-to-phenylalanine codon reassignment (W>F)...

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Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

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Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8942854

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8942854

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ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-022-04499-2

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