Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
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Author / Creator
Pataskar, Abhijeet , Champagne, Julien , Nagel, Remco , Kenski, Juliana , Laos, Maarja , Michaux, Justine , Pak, Hui Song , Bleijerveld, Onno B. , Mordente, Kelly , Navarro, Jasmine Montenegro , Blommaert, Naomi , Nielsen, Morten M. , Lovecchio, Domenica , Stone, Everett , Georgiou, George , de Gooijer, Mark C. , van Tellingen, Olaf , Altelaar, Maarten , Joosten, Robbie P. , Perrakis, Anastassis , Olweus, Johanna , Bassani-Sternberg, Michal , Peeper, Daniel S. and Agami, Reuven
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Activated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme
1
–
4
. Here we show that despite tryptophan depletion, in-frame protein synthesis continues across tryptophan codons. We identified tryptophan-to-phenylalanine codon reassignment (W>F)...
Alternative Titles
Full title
Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
Authors, Artists and Contributors
Author / Creator
Champagne, Julien
Nagel, Remco
Kenski, Juliana
Laos, Maarja
Michaux, Justine
Pak, Hui Song
Bleijerveld, Onno B.
Mordente, Kelly
Navarro, Jasmine Montenegro
Blommaert, Naomi
Nielsen, Morten M.
Lovecchio, Domenica
Stone, Everett
Georgiou, George
de Gooijer, Mark C.
van Tellingen, Olaf
Altelaar, Maarten
Joosten, Robbie P.
Perrakis, Anastassis
Olweus, Johanna
Bassani-Sternberg, Michal
Peeper, Daniel S.
Agami, Reuven
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8942854
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8942854
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04499-2