Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
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Author / Creator
Ecuador-COVID19 Consortium , The CITIID-NIHR BioResource COVID-19 Collaboration , The Genotype to Phenotype Japan (G2P-Japan) Consortium , Genotype to Phenotype Japan (G2P-Japan) Consortium , CITIID-NIHR BioResource COVID-19 Collaboration , Meng, Bo , Abdullahi, Adam , Ferreira, Isabella A. T. M. , Goonawardane, Niluka , Saito, Akatsuki , Kimura, Izumi , Yamasoba, Daichi , Gerber, Pehuén Pereyra , Fatihi, Saman , Rathore, Surabhi , Zepeda, Samantha K. , Papa, Guido , Kemp, Steven A. , Ikeda, Terumasa , Toyoda, Mako , Tan, Toong Seng , Kuramochi, Jin , Mitsunaga, Shigeki , Ueno, Takamasa , Shirakawa, Kotaro , Takaori-Kondo, Akifumi , Brevini, Teresa , Mallery, Donna L. , Charles, Oscar J. , Bowen, John E. , Joshi, Anshu , Walls, Alexandra C. , Jackson, Laurelle , Martin, Darren , Smith, Kenneth G. C. , Bradley, John , Briggs, John A. G. , Choi, Jinwook , Madissoon, Elo , Meyer, Kerstin B. , Mlcochova, Petra , Ceron-Gutierrez, Lourdes , Doffinger, Rainer , Teichmann, Sarah A. , Fisher, Andrew J. , Pizzuto, Matteo S. , de Marco, Anna , Corti, Davide , Hosmillo, Myra , Lee, Joo Hyeon , James, Leo C. , Thukral, Lipi , Veesler, David , Sigal, Alex , Sampaziotis, Fotios , Goodfellow, Ian G. , Matheson, Nicholas J. , Sato, Kei and Gupta, Ravindra K.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The SARS-CoV-2 Omicron BA.1 variant emerged in 2021
1
and has multiple mutations in its spike protein
2
. Here we show that the spike protein of Omicron has a higher affinity for ACE2 compared with Delta, and a marked change in its antigenicity increases Omicron’s evasion of therapeutic monoclonal and vaccine-elicited polyclonal neutral...
Alternative Titles
Full title
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
Authors, Artists and Contributors
Author / Creator
The CITIID-NIHR BioResource COVID-19 Collaboration
The Genotype to Phenotype Japan (G2P-Japan) Consortium
Genotype to Phenotype Japan (G2P-Japan) Consortium
CITIID-NIHR BioResource COVID-19 Collaboration
Meng, Bo
Abdullahi, Adam
Ferreira, Isabella A. T. M.
Goonawardane, Niluka
Saito, Akatsuki
Kimura, Izumi
Yamasoba, Daichi
Gerber, Pehuén Pereyra
Fatihi, Saman
Rathore, Surabhi
Zepeda, Samantha K.
Papa, Guido
Kemp, Steven A.
Ikeda, Terumasa
Toyoda, Mako
Tan, Toong Seng
Kuramochi, Jin
Mitsunaga, Shigeki
Ueno, Takamasa
Shirakawa, Kotaro
Takaori-Kondo, Akifumi
Brevini, Teresa
Mallery, Donna L.
Charles, Oscar J.
Bowen, John E.
Joshi, Anshu
Walls, Alexandra C.
Jackson, Laurelle
Martin, Darren
Smith, Kenneth G. C.
Bradley, John
Briggs, John A. G.
Choi, Jinwook
Madissoon, Elo
Meyer, Kerstin B.
Mlcochova, Petra
Ceron-Gutierrez, Lourdes
Doffinger, Rainer
Teichmann, Sarah A.
Fisher, Andrew J.
Pizzuto, Matteo S.
de Marco, Anna
Corti, Davide
Hosmillo, Myra
Lee, Joo Hyeon
James, Leo C.
Thukral, Lipi
Veesler, David
Sigal, Alex
Sampaziotis, Fotios
Goodfellow, Ian G.
Matheson, Nicholas J.
Sato, Kei
Gupta, Ravindra K.
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8942856
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8942856
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04474-x
