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Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis

Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8990011

Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis

About this item

Full title

Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis

Publisher

London: Nature Publishing Group UK

Journal title

Cell death and differentiation, 2022-04, Vol.29 (4), p.788-805

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Anti-apoptotic Bcl-2-family members not only act at mitochondria but also at the endoplasmic reticulum, where they impact Ca
2+
dynamics by controlling IP
3
receptor (IP
3
R) function. Current models propose distinct roles for Bcl-2
vs.
Bcl-xL, with Bcl-2 inhibiting IP
3
Rs and preventing pro-apoptotic Ca
2+
rele...

Alternative Titles

Full title

Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8990011

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8990011

Other Identifiers

ISSN

1350-9047

E-ISSN

1476-5403

DOI

10.1038/s41418-021-00894-w

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