Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis
Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis
About this item
Full title
Author / Creator
Rosa, Nicolas , Ivanova, Hristina , Wagner, Larry E. , Kale, Justin , La Rovere, Rita , Welkenhuyzen, Kirsten , Louros, Nikolaos , Karamanou, Spyridoula , Shabardina, Victoria , Lemmens, Irma , Vandermarliere, Elien , Hamada, Kozo , Ando, Hideaki , Rousseau, Frederic , Schymkowitz, Joost , Tavernier, Jan , Mikoshiba, Katsuhiko , Economou, Anastassios , Andrews, David W. , Parys, Jan B. , Yule, David I. and Bultynck, Geert
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Anti-apoptotic Bcl-2-family members not only act at mitochondria but also at the endoplasmic reticulum, where they impact Ca
2+
dynamics by controlling IP
3
receptor (IP
3
R) function. Current models propose distinct roles for Bcl-2
vs.
Bcl-xL, with Bcl-2 inhibiting IP
3
Rs and preventing pro-apoptotic Ca
2+
rele...
Alternative Titles
Full title
Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis
Authors, Artists and Contributors
Author / Creator
Ivanova, Hristina
Wagner, Larry E.
Kale, Justin
La Rovere, Rita
Welkenhuyzen, Kirsten
Louros, Nikolaos
Karamanou, Spyridoula
Shabardina, Victoria
Lemmens, Irma
Vandermarliere, Elien
Hamada, Kozo
Ando, Hideaki
Rousseau, Frederic
Schymkowitz, Joost
Tavernier, Jan
Mikoshiba, Katsuhiko
Economou, Anastassios
Andrews, David W.
Parys, Jan B.
Yule, David I.
Bultynck, Geert
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8990011
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8990011
Other Identifiers
ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/s41418-021-00894-w
