The multi-specific VH-based Humabody CB213 co-targets PD1 and LAG3 on T cells to promote anti-tumour...
The multi-specific VH-based Humabody CB213 co-targets PD1 and LAG3 on T cells to promote anti-tumour activity
About this item
Full title
Author / Creator
Edwards, Carolyn J. , Sette, Angelica , Cox, Carl , Di Fiore, Barbara , Wyre, Chris , Sydoruk, Daniela , Yadin, David , Hayes, Philip , Stelter, Szymon , Bartlett, Phillip D. , Zuazo, Miren , Garcia-Granda, Maria Jesus , Benedetti, Giovanni , Fiaska, Stratoniki , Birkett, Neil R. , Teng, Yumin , Enever, Carrie , Arasanz, Hugo , Bocanegra, Ana , Chocarro, Luisa , Fernandez, Gonzalo , Vera, Ruth , Archer, Bethan , Osuch, Isabelle , Lewandowska, Martyna , Surani, Yasmin M. , Kochan, Grazyna , Escors, David , Legg, James and Pierce, Andrew J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Background
Improving cancer immunotherapy long-term clinical benefit is a major priority. It has become apparent that multiple axes of immune suppression restrain the capacity of T cells to provide anti-tumour activity including signalling through PD1/PD-L1 and LAG3/MHC-II.
Methods
CB213 has been developed as a fully human PD1/LAG3 co-targ...
Alternative Titles
Full title
The multi-specific VH-based Humabody CB213 co-targets PD1 and LAG3 on T cells to promote anti-tumour activity
Authors, Artists and Contributors
Author / Creator
Sette, Angelica
Cox, Carl
Di Fiore, Barbara
Wyre, Chris
Sydoruk, Daniela
Yadin, David
Hayes, Philip
Stelter, Szymon
Bartlett, Phillip D.
Zuazo, Miren
Garcia-Granda, Maria Jesus
Benedetti, Giovanni
Fiaska, Stratoniki
Birkett, Neil R.
Teng, Yumin
Enever, Carrie
Arasanz, Hugo
Bocanegra, Ana
Chocarro, Luisa
Fernandez, Gonzalo
Vera, Ruth
Archer, Bethan
Osuch, Isabelle
Lewandowska, Martyna
Surani, Yasmin M.
Kochan, Grazyna
Escors, David
Legg, James
Pierce, Andrew J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9023588
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9023588
Other Identifiers
ISSN
0007-0920
E-ISSN
1532-1827
DOI
10.1038/s41416-021-01684-4
