Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regula...
Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk
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Author / Creator
Chiou, Joshua , Zeng, Chun , Cheng, Zhang , Han, Jee Yun , Schlichting, Michael , Miller, Michael , Mendez, Robert , Huang, Serina , Wang, Jinzhao , Sui, Yinghui , Deogaygay, Allison , Okino, Mei-Lin , Qiu, Yunjiang , Sun, Ying , Kudtarkar, Parul , Fang, Rongxin , Preissl, Sebastian , Sander, Maike , Gorkin, David U. and Gaulton, Kyle J.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq) creates new opportunities to dissect cell type–specific mechanisms of complex diseases. Since pancreatic islets are central to type 2 diabetes (T2D), we profiled 15,298 islet cells by using combinatorial barcoding snATAC-seq and identified 12 clusters, including...
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Full title
Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9037575
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9037575
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-021-00823-0
