Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1
Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1
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Author / Creator
Qu, Xiangli , Qiu, Na , Wang, Mu , Zhang, Bingjie , Du, Juan , Zhong, Zhiwei , Xu, Wei , Chu, Xiaojing , Ma, Limin , Yi, Cuiying , Han, Shuo , Shui, Wenqing , Zhao, Qiang and Wu, Beili
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Adhesion G protein-coupled receptors (aGPCRs) are essential for a variety of physiological processes such as immune responses, organ development, cellular communication, proliferation and homeostasis
1
–
7
. An intrinsic manner of activation that involves a tethered agonist in the N-terminal region of the receptor has been proposed for...
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Full title
Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9046087
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9046087
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04580-w
