CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition
CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition
About this item
Full title
Author / Creator
Gallo, David , Young, Jordan T. F. , Fourtounis, Jimmy , Martino, Giovanni , Álvarez-Quilón, Alejandro , Bernier, Cynthia , Duffy, Nicole M. , Papp, Robert , Roulston, Anne , Stocco, Rino , Szychowski, Janek , Veloso, Artur , Alam, Hunain , Baruah, Prasamit S. , Fortin, Alexanne Bonneau , Bowlan, Julian , Chaudhary, Natasha , Desjardins, Jessica , Dietrich, Evelyne , Fournier, Sara , Fugère-Desjardins, Chloe , Goullet de Rugy, Theo , Leclaire, Marie-Eve , Liu, Bingcan , Bhaskaran, Vivek , Mamane, Yael , Melo, Henrique , Nicolas, Olivier , Singhania, Akul , Szilard, Rachel K. , Tkáč, Ján , Yin, Shou Yun , Morris, Stephen J. , Zinda, Michael , Marshall, C. Gary and Durocher, Daniel
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Amplification of the
CCNE1
locus on chromosome 19q12 is prevalent in multiple tumour types, particularly in high-grade serous ovarian cancer, uterine tumours and gastro-oesophageal cancers, where high cyclin E levels are associated with genome instability, whole-genome doubling and resistance to cytotoxic and targeted therapies
1
–
4...
Alternative Titles
Full title
CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition
Authors, Artists and Contributors
Author / Creator
Young, Jordan T. F.
Fourtounis, Jimmy
Martino, Giovanni
Álvarez-Quilón, Alejandro
Bernier, Cynthia
Duffy, Nicole M.
Papp, Robert
Roulston, Anne
Stocco, Rino
Szychowski, Janek
Veloso, Artur
Alam, Hunain
Baruah, Prasamit S.
Fortin, Alexanne Bonneau
Bowlan, Julian
Chaudhary, Natasha
Desjardins, Jessica
Dietrich, Evelyne
Fournier, Sara
Fugère-Desjardins, Chloe
Goullet de Rugy, Theo
Leclaire, Marie-Eve
Liu, Bingcan
Bhaskaran, Vivek
Mamane, Yael
Melo, Henrique
Nicolas, Olivier
Singhania, Akul
Szilard, Rachel K.
Tkáč, Ján
Yin, Shou Yun
Morris, Stephen J.
Zinda, Michael
Marshall, C. Gary
Durocher, Daniel
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9046089
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9046089
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04638-9
