Is Poor Lithium Response in Individuals with Bipolar Disorder Associated with Increased Degradation...
Is Poor Lithium Response in Individuals with Bipolar Disorder Associated with Increased Degradation of Tryptophan along the Kynurenine Pathway? Results of an Exploratory Study
About this item
Full title
Author / Creator
Fellendorf, Frederike T , Manchia, Mirko , Squassina, Alessio , Pisanu, Claudia , Dall'Acqua, Stefano , Sut, Stefania , Nasini, Sofia , Congiu, Donatella , Reininghaus, Eva Z , Garzilli, Mario , Guiso, Beatrice , Suprani, Federico , Paribello, Pasquale , Pulcinelli, Vittoria , Iaselli, Maria Novella , Pinna, Ilaria , Somaini, Giulia , Arru, Laura , Corrias, Carolina , Pinna, Federica , Carpiniello, Bernardo and Comai, Stefano
Publisher
Switzerland: MDPI AG
Journal title
Language
English
Formats
Publication information
Publisher
Switzerland: MDPI AG
Subjects
More information
Scope and Contents
Contents
Bipolar disorder is associated with an inflammation-triggered elevated catabolism of tryptophan to the kynurenine pathway, which impacts psychiatric symptoms and outcomes. The data indicate that lithium exerts anti-inflammatory effects by inhibiting indoleamine-2,3-dioxygenase (IDO)-1 activity. This exploratory study aimed to investigate the trypto...
Alternative Titles
Full title
Is Poor Lithium Response in Individuals with Bipolar Disorder Associated with Increased Degradation of Tryptophan along the Kynurenine Pathway? Results of an Exploratory Study
Authors, Artists and Contributors
Author / Creator
Manchia, Mirko
Squassina, Alessio
Pisanu, Claudia
Dall'Acqua, Stefano
Sut, Stefania
Nasini, Sofia
Congiu, Donatella
Reininghaus, Eva Z
Garzilli, Mario
Guiso, Beatrice
Suprani, Federico
Paribello, Pasquale
Pulcinelli, Vittoria
Iaselli, Maria Novella
Pinna, Ilaria
Somaini, Giulia
Arru, Laura
Corrias, Carolina
Pinna, Federica
Carpiniello, Bernardo
Comai, Stefano
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9103936
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9103936
Other Identifiers
ISSN
2077-0383
E-ISSN
2077-0383
DOI
10.3390/jcm11092517
