ecDNA hubs drive cooperative intermolecular oncogene expression
ecDNA hubs drive cooperative intermolecular oncogene expression
About this item
Full title
Author / Creator
Hung, King L. , Yost, Kathryn E. , Xie, Liangqi , Shi, Quanming , Helmsauer, Konstantin , Luebeck, Jens , Schöpflin, Robert , Lange, Joshua T. , Chamorro González, Rocío , Weiser, Natasha E. , Chen, Celine , Valieva, Maria E. , Wong, Ivy Tsz-Lo , Wu, Sihan , Dehkordi, Siavash R. , Duffy, Connor V. , Kraft, Katerina , Tang, Jun , Belk, Julia A. , Rose, John C. , Corces, M. Ryan , Granja, Jeffrey M. , Li, Rui , Rajkumar, Utkrisht , Friedlein, Jordan , Bagchi, Anindya , Satpathy, Ansuman T. , Tjian, Robert , Mundlos, Stefan , Bafna, Vineet , Henssen, Anton G. , Mischel, Paul S. , Liu, Zhe and Chang, Howard Y.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high expression of oncogenes through gene amplification and altered gene regulation
1
. Gene induction typically involves
cis
-regulatory elements that contact and activate genes on the same chromosome
2
,
3
. Here we show that ecDNA hubs—clusters of aro...
Alternative Titles
Full title
ecDNA hubs drive cooperative intermolecular oncogene expression
Authors, Artists and Contributors
Author / Creator
Yost, Kathryn E.
Xie, Liangqi
Shi, Quanming
Helmsauer, Konstantin
Luebeck, Jens
Schöpflin, Robert
Lange, Joshua T.
Chamorro González, Rocío
Weiser, Natasha E.
Chen, Celine
Valieva, Maria E.
Wong, Ivy Tsz-Lo
Wu, Sihan
Dehkordi, Siavash R.
Duffy, Connor V.
Kraft, Katerina
Tang, Jun
Belk, Julia A.
Rose, John C.
Corces, M. Ryan
Granja, Jeffrey M.
Li, Rui
Rajkumar, Utkrisht
Friedlein, Jordan
Bagchi, Anindya
Satpathy, Ansuman T.
Tjian, Robert
Mundlos, Stefan
Bafna, Vineet
Henssen, Anton G.
Mischel, Paul S.
Liu, Zhe
Chang, Howard Y.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9126690
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9126690
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-021-04116-8
