Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs
Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs
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Author / Creator
Eschweiler, Simon , Ramírez-Suástegui, Ciro , Li, Yingcong , King, Emma , Chudley, Lindsey , Thomas, Jaya , Wood, Oliver , von Witzleben, Adrian , Jeffrey, Danielle , McCann, Katy , Simon, Hayley , Mondal, Monalisa , Wang, Alice , Dicker, Martina , Lopez-Guadamillas, Elena , Chou, Ting-Fang , Dobbs, Nicola A. , Essame, Louisa , Acton, Gary , Kelly, Fiona , Halbert, Gavin , Sacco, Joseph J. , Schache, Andrew Graeme , Shaw, Richard , McCaul, James Anthony , Paterson, Claire , Davies, Joseph H. , Brennan, Peter A. , Singh, Rabindra P. , Loadman, Paul M. , Wilson, William , Hackshaw, Allan , Seumois, Gregory , Okkenhaug, Klaus , Thomas, Gareth J. , Jones, Terry M. , Ay, Ferhat , Friberg, Greg , Kronenberg, Mitchell , Vanhaesebroeck, Bart , Vijayanand, Pandurangan and Ottensmeier, Christian H.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Phosphoinositide 3-kinase δ (PI3Kδ) has a key role in lymphocytes, and inhibitors that target this PI3K have been approved for treatment of B cell malignancies
1
–
3
. Although studies in mouse models of solid tumours have demonstrated that PI3Kδ inhibitors (PI3Kδi) can induce anti-tumour immunity
4
,
5
, its effect on solid...
Alternative Titles
Full title
Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs
Authors, Artists and Contributors
Author / Creator
Ramírez-Suástegui, Ciro
Li, Yingcong
King, Emma
Chudley, Lindsey
Thomas, Jaya
Wood, Oliver
von Witzleben, Adrian
Jeffrey, Danielle
McCann, Katy
Simon, Hayley
Mondal, Monalisa
Wang, Alice
Dicker, Martina
Lopez-Guadamillas, Elena
Chou, Ting-Fang
Dobbs, Nicola A.
Essame, Louisa
Acton, Gary
Kelly, Fiona
Halbert, Gavin
Sacco, Joseph J.
Schache, Andrew Graeme
Shaw, Richard
McCaul, James Anthony
Paterson, Claire
Davies, Joseph H.
Brennan, Peter A.
Singh, Rabindra P.
Loadman, Paul M.
Wilson, William
Hackshaw, Allan
Seumois, Gregory
Okkenhaug, Klaus
Thomas, Gareth J.
Jones, Terry M.
Ay, Ferhat
Friberg, Greg
Kronenberg, Mitchell
Vanhaesebroeck, Bart
Vijayanand, Pandurangan
Ottensmeier, Christian H.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9132770
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9132770
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04685-2
