αSMA+ fibroblasts suppress Lgr5+ cancer stem cells and restrain colorectal cancer progression
αSMA+ fibroblasts suppress Lgr5+ cancer stem cells and restrain colorectal cancer progression
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The development and progression of solid tumors is dependent on cancer cell autonomous drivers and the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) in the TME possess both tumor-promoting and tumor-restraining functions. In the current study, we interrogated the role of αSMA
+
CAFs in a genetic mouse model of metastatic...
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Full title
αSMA+ fibroblasts suppress Lgr5+ cancer stem cells and restrain colorectal cancer progression
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9150816
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9150816
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-021-01866-7
