STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity
STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity
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Author / Creator
Dane, Eric L. , Belessiotis-Richards, Alexis , Backlund, Coralie , Wang, Jianing , Hidaka, Kousuke , Milling, Lauren E. , Bhagchandani, Sachin , Melo, Mariane B. , Wu, Shengwei , Li, Na , Donahue, Nathan , Ni, Kaiyuan , Ma, Leyuan , Okaniwa, Masanori , Stevens, Molly M. , Alexander-Katz, Alfredo and Irvine, Darrell J.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Activation of the innate immune STimulator of INterferon Genes (STING) pathway potentiates antitumour immunity, but systemic delivery of STING agonists to tumours is challenging. We conjugated STING-activating cyclic dinucleotides (CDNs) to PEGylated lipids (CDN-PEG-lipids; PEG, polyethylene glycol) via a cleavable linker and incorporated them into...
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Full title
STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9156412
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9156412
Other Identifiers
ISSN
1476-1122
E-ISSN
1476-4660
DOI
10.1038/s41563-022-01251-z
