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Clonal dynamics of haematopoiesis across the human lifespan

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Clonal dynamics of haematopoiesis across the human lifespan

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9177428

Clonal dynamics of haematopoiesis across the human lifespan

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London: Nature Publishing Group UK

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Contents

Age-related change in human haematopoiesis causes reduced regenerative capacity
1
, cytopenias
2
, immune dysfunction
3
and increased risk of blood cancer
4
–
6
, but the reason for such abrupt functional decline after 70 years of age remains unclear. Here we sequenced 3,579 genomes from single cell-derived colonies of...

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Clonal dynamics of haematopoiesis across the human lifespan

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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9177428

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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9177428

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ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-022-04786-y

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