Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis
Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis
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Author / Creator
Chan, Jia Jia , Zhang, Bin , Chew, Xiao Hong , Salhi, Adil , Kwok, Zhi Hao , Lim, Chun You , Desi, Ng , Subramaniam, Nagavidya , Siemens, Angela , Kinanti, Tyas , Ong, Shane , Sanchez-Mejias, Avencia , Ly, Phuong Thao , An, Omer , Sundar, Raghav , Fan, Xiaonan , Wang, Shi , Siew, Bei En , Lee, Kuok Chung , Chong, Choon Seng , Lieske, Bettina , Cheong, Wai-Kit , Goh, Yufen , Fam, Wee Nih , Ooi, Melissa G. , Koh, Bryan T. H. , Iyer, Shridhar Ganpathi , Ling, Wen Huan , Chen, Jianbin , Yoong, Boon-Koon , Chanwat, Rawisak , Bonney, Glenn Kunnath , Goh, Brian K. P. , Zhai, Weiwei , Fullwood, Melissa J. , Wang, Wilson , Tan, Ker-Kan , Chng, Wee Joo , Dan, Yock Young , Pitt, Jason J. , Roca, Xavier , Guccione, Ernesto , Vardy, Leah A. , Chen, Leilei , Gao, Xin , Chow, Pierce K. H. , Yang, Henry and Tay, Yvonne
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Most mammalian genes generate messenger RNAs with variable untranslated regions (UTRs) that are important post-transcriptional regulators. In cancer, shortening at 3′ UTR ends via alternative polyadenylation can activate oncogenes. However, internal 3′ UTR splicing remains poorly understood as splicing studies have traditionally focused on protein-coding alterations. Here we systematically map the pan-cancer landscape of 3′ UTR splicing and present this in SpUR (
http://www.cbrc.kaust.edu.sa/spur/home/
). 3′ UTR splicing is widespread, upregulated in cancers, correlated with poor prognosis and more prevalent in oncogenes. We show that antisense oligonucleotide-mediated inhibition of 3′ UTR splicing efficiently reduces oncogene expression and impedes tumour progression. Notably,
CTNNB1
3′ UTR splicing is the most consistently dysregu...
Alternative Titles
Full title
Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis
Authors, Artists and Contributors
Author / Creator
Zhang, Bin
Chew, Xiao Hong
Salhi, Adil
Kwok, Zhi Hao
Lim, Chun You
Desi, Ng
Subramaniam, Nagavidya
Siemens, Angela
Kinanti, Tyas
Ong, Shane
Sanchez-Mejias, Avencia
Ly, Phuong Thao
An, Omer
Sundar, Raghav
Fan, Xiaonan
Wang, Shi
Siew, Bei En
Lee, Kuok Chung
Chong, Choon Seng
Lieske, Bettina
Cheong, Wai-Kit
Goh, Yufen
Fam, Wee Nih
Ooi, Melissa G.
Koh, Bryan T. H.
Iyer, Shridhar Ganpathi
Ling, Wen Huan
Chen, Jianbin
Yoong, Boon-Koon
Chanwat, Rawisak
Bonney, Glenn Kunnath
Goh, Brian K. P.
Zhai, Weiwei
Fullwood, Melissa J.
Wang, Wilson
Tan, Ker-Kan
Chng, Wee Joo
Dan, Yock Young
Pitt, Jason J.
Roca, Xavier
Guccione, Ernesto
Vardy, Leah A.
Chen, Leilei
Gao, Xin
Chow, Pierce K. H.
Yang, Henry
Tay, Yvonne
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9203280
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9203280
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-022-00913-z
