ADAR1 mutation causes ZBP1-dependent immunopathology
ADAR1 mutation causes ZBP1-dependent immunopathology
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The RNA-editing enzyme ADAR1 is essential for the suppression of innate immune activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by disrupting the duplex structure of endogenous double-stranded RNA species
1
,
2
. A point mutation in the sequence encoding the Z-DNA-binding domain (ZBD) of ADAR1 i...
Alternative Titles
Full title
ADAR1 mutation causes ZBP1-dependent immunopathology
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9339495
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9339495
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ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04896-7
