PTEN Dual Lipid- and Protein-Phosphatase Function in Tumor Progression
PTEN Dual Lipid- and Protein-Phosphatase Function in Tumor Progression
About this item
Full title
Author / Creator
Liu, Anne , Zhu, Yanyu , Chen, Weiping , Merlino, Glenn and Yu, Yanlin
Publisher
Basel: MDPI AG
Journal title
Language
English
Formats
Publication information
Publisher
Basel: MDPI AG
Subjects
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Scope and Contents
Contents
PTEN is the second most highly mutated tumor suppressor in cancer, following only p53. The PTEN protein functions as a phosphatase with lipid- and protein-phosphatase activity. PTEN-lipid-phosphatase activity dephosphorylates PIP3 to form PIP2, and it then antagonizes PI3K and blocks the activation of AKT, while its protein-phosphatase activity dep...
Alternative Titles
Full title
PTEN Dual Lipid- and Protein-Phosphatase Function in Tumor Progression
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9367293
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9367293
Other Identifiers
ISSN
2072-6694
E-ISSN
2072-6694
DOI
10.3390/cancers14153666
