Cryo-EM structures of prion protein filaments from Gerstmann–Sträussler–Scheinker disease
Cryo-EM structures of prion protein filaments from Gerstmann–Sträussler–Scheinker disease
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Berlin/Heidelberg: Springer Berlin Heidelberg
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Language
English
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Berlin/Heidelberg: Springer Berlin Heidelberg
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Contents
Prion protein (PrP) aggregation and formation of PrP amyloid (APrP) are central events in the pathogenesis of prion diseases. In the dominantly inherited prion protein amyloidosis known as Gerstmann–Sträussler–Scheinker (GSS) disease, plaques made of PrP amyloid are present throughout the brain. The c.593t > c mutation in the prion protein gene (
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Full title
Cryo-EM structures of prion protein filaments from Gerstmann–Sträussler–Scheinker disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9381446
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9381446
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ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-022-02461-0
