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Structural basis of GABA reuptake inhibition

Structural basis of GABA reuptake inhibition

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9394549

Structural basis of GABA reuptake inhibition

About this item

Full title

Structural basis of GABA reuptake inhibition

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2022-06, Vol.606 (7915), p.820-826

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

γ-Aminobutyric acid (GABA) transporter 1 (GAT1)
1
regulates neuronal excitation of the central nervous system by clearing the synaptic cleft of the inhibitory neurotransmitter GABA upon its release from synaptic vesicles. Elevating the levels of GABA in the synaptic cleft, by inhibiting GABA reuptake transporters, is an established strategy t...

Alternative Titles

Full title

Structural basis of GABA reuptake inhibition

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9394549

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9394549

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-022-04814-x

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