Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
About this item
Full title
Author / Creator
Gui, Xiang , Yang, Hui , Li, Tuo , Tan, Xiaojun , Shi, Peiqing , Li, Minghao , Du, Fenghe and Chen, Zhijian J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self DNA in the cytoplasm
1
. Upon binding DNA, cGAS produces cGAMP that binds to and activates the adaptor protein STING, which then activates the kinases IKK and TBK1 to induce interferons and other cytokines
2
–
6
. Here we rep...
Alternative Titles
Full title
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9417302
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9417302
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1006-9
