DFV890: a new oral NLRP3 inhibitor—tested in an early phase 2a randomised clinical trial in patients...
DFV890: a new oral NLRP3 inhibitor—tested in an early phase 2a randomised clinical trial in patients with COVID-19 pneumonia and impaired respiratory function
About this item
Full title
Author / Creator
Madurka, Ildiko , Vishnevsky, Alexander , Soriano, Joan B. , Gans, Stephanus J. , Ore, Danilo Joel Salazar , Rendon, Adrian , Ulrik, Charlotte S. , Bhatnagar, Sushma , Krishnamurthy, Srikanth , Mc Harry, Kirsten , Welte, Tobias , Fernandez, Alberto A. , Mehes, Beata , Meiser, Karin , Gatlik, Ewa , Sommer, Ulrike , Junge, Guido , Rezende, Ederlon and Study group
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Background
Coronavirus-associated acute respiratory distress syndrome (CARDS) has limited effective therapy to date. NLRP3 inflammasome activation induced by SARS-CoV-2 in COVID-19 contributes to cytokine storm.
Methods
This randomised, multinational study enrolled hospitalised patients (18–80 years) with COVID-19-associated pneumonia and...
Alternative Titles
Full title
DFV890: a new oral NLRP3 inhibitor—tested in an early phase 2a randomised clinical trial in patients with COVID-19 pneumonia and impaired respiratory function
Authors, Artists and Contributors
Author / Creator
Vishnevsky, Alexander
Soriano, Joan B.
Gans, Stephanus J.
Ore, Danilo Joel Salazar
Rendon, Adrian
Ulrik, Charlotte S.
Bhatnagar, Sushma
Krishnamurthy, Srikanth
Mc Harry, Kirsten
Welte, Tobias
Fernandez, Alberto A.
Mehes, Beata
Meiser, Karin
Gatlik, Ewa
Sommer, Ulrike
Junge, Guido
Rezende, Ederlon
Study group
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9473473
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9473473
Other Identifiers
ISSN
0300-8126
E-ISSN
1439-0973
DOI
10.1007/s15010-022-01904-w
