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A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein

A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9512702

A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein

About this item

Full title

A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein

Publisher

New York: Nature Publishing Group US

Journal title

Nature chemical biology, 2022-10, Vol.18 (10), p.1046-1055

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Protein tertiary structure mimetics are valuable tools to target large protein–protein interaction interfaces. Here, we demonstrate a strategy for designing dimeric helix-hairpin motifs from a previously reported three-helix-bundle miniprotein that targets the receptor-binding domain (RBD) of severe acute respiratory syndrome-coronavirus-2 (SARS-Co...

Alternative Titles

Full title

A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9512702

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9512702

Other Identifiers

ISSN

1552-4450,1552-4469

E-ISSN

1552-4469

DOI

10.1038/s41589-022-01060-0

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