Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
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Author / Creator
Cameroni, Elisabetta , Bowen, John E. , Rosen, Laura E. , Saliba, Christian , Zepeda, Samantha K. , Culap, Katja , Pinto, Dora , VanBlargan, Laura A. , De Marco, Anna , di Iulio, Julia , Zatta, Fabrizia , Kaiser, Hannah , Noack, Julia , Farhat, Nisar , Czudnochowski, Nadine , Havenar-Daughton, Colin , Sprouse, Kaitlin R. , Dillen, Josh R. , Powell, Abigail E. , Chen, Alex , Maher, Cyrus , Yin, Li , Sun, David , Soriaga, Leah , Bassi, Jessica , Silacci-Fregni, Chiara , Gustafsson, Claes , Franko, Nicholas M. , Logue, Jenni , Iqbal, Najeeha Talat , Mazzitelli, Ignacio , Geffner, Jorge , Grifantini, Renata , Chu, Helen , Gori, Andrea , Riva, Agostino , Giannini, Olivier , Ceschi, Alessandro , Ferrari, Paolo , Cippà, Pietro E. , Franzetti-Pellanda, Alessandra , Garzoni, Christian , Halfmann, Peter J. , Kawaoka, Yoshihiro , Hebner, Christy , Purcell, Lisa A. , Piccoli, Luca , Pizzuto, Matteo Samuele , Walls, Alexandra C. , Diamond, Michael S. , Telenti, Amalio , Virgin, Herbert W. , Lanzavecchia, Antonio , Snell, Gyorgy , Veesler, David and Corti, Davide
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising concerns about the effectiveness of available vaccines and antibody-based therapeutics. Here we show that the Omicron RBD binds to human ACE2 with enhanced affinity, relative...
Alternative Titles
Full title
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
Authors, Artists and Contributors
Author / Creator
Bowen, John E.
Rosen, Laura E.
Saliba, Christian
Zepeda, Samantha K.
Culap, Katja
Pinto, Dora
VanBlargan, Laura A.
De Marco, Anna
di Iulio, Julia
Zatta, Fabrizia
Kaiser, Hannah
Noack, Julia
Farhat, Nisar
Czudnochowski, Nadine
Havenar-Daughton, Colin
Sprouse, Kaitlin R.
Dillen, Josh R.
Powell, Abigail E.
Chen, Alex
Maher, Cyrus
Yin, Li
Sun, David
Soriaga, Leah
Bassi, Jessica
Silacci-Fregni, Chiara
Gustafsson, Claes
Franko, Nicholas M.
Logue, Jenni
Iqbal, Najeeha Talat
Mazzitelli, Ignacio
Geffner, Jorge
Grifantini, Renata
Chu, Helen
Gori, Andrea
Riva, Agostino
Giannini, Olivier
Ceschi, Alessandro
Ferrari, Paolo
Cippà, Pietro E.
Franzetti-Pellanda, Alessandra
Garzoni, Christian
Halfmann, Peter J.
Kawaoka, Yoshihiro
Hebner, Christy
Purcell, Lisa A.
Piccoli, Luca
Pizzuto, Matteo Samuele
Walls, Alexandra C.
Diamond, Michael S.
Telenti, Amalio
Virgin, Herbert W.
Lanzavecchia, Antonio
Snell, Gyorgy
Veesler, David
Corti, Davide
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9531318
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9531318
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-021-04386-2
