Asparagine bioavailability regulates the translation of MYC oncogene
Asparagine bioavailability regulates the translation of MYC oncogene
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Amino acid restriction has recently emerged as a compelling strategy to inhibit tumor growth. Recent work suggests that amino acids can regulate cellular signaling in addition to their role as biosynthetic substrates. Using lymphoid cancer cells as a model, we found that asparagine depletion acutely reduces the expression of c-MYC protein without c...
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Asparagine bioavailability regulates the translation of MYC oncogene
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9617787
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9617787
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ISSN
0950-9232,1476-5594
E-ISSN
1476-5594
DOI
10.1038/s41388-022-02474-9
