Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor...
Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION): overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial
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Author / Creator
Howell, Sacha J, FRCP , Casbard, Angela, MSc , Carucci, Margherita, PhD , Ingarfield, Kate, PhD , Butler, Rachel, Prof , Morgan, Sian, FRCPath , Meissner, Magdalena, MRCP , Bale, Catherine, FRCP , Bezecny, Pavel, MD , Moon, Sarah, BM BCh , Twelves, Chris, Prof , Venkitaraman, Ramachandran, FRCR , Waters, Simon, FRCP , de Bruin, Elza C, PhD , Schiavon, Gaia, MD PhD , Foxley, Andrew, BA and Jones, Robert H, FRCP
Publisher
England: Elsevier Ltd
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Language
English
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Publisher
England: Elsevier Ltd
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Contents
SummaryBackgroundCapivasertib, an AKT inhibitor, added to fulvestrant, was previously reported to improve progression-free survival in women with aromatase inhibitor-resistant oestrogen receptor (ER)-positive, HER2-negative advanced breast cancer. The benefit appeared to be independent of the phosphoinositide 3-kinase (PI3K)/AKT/phosphatase and ten...
Alternative Titles
Full title
Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION): overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial
Authors, Artists and Contributors
Author / Creator
Casbard, Angela, MSc
Carucci, Margherita, PhD
Ingarfield, Kate, PhD
Butler, Rachel, Prof
Morgan, Sian, FRCPath
Meissner, Magdalena, MRCP
Bale, Catherine, FRCP
Bezecny, Pavel, MD
Moon, Sarah, BM BCh
Twelves, Chris, Prof
Venkitaraman, Ramachandran, FRCR
Waters, Simon, FRCP
de Bruin, Elza C, PhD
Schiavon, Gaia, MD PhD
Foxley, Andrew, BA
Jones, Robert H, FRCP
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9630162
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9630162
Other Identifiers
ISSN
1470-2045
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(22)00284-4
