CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory react...
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states
About this item
Full title
Author / Creator
Leng, Kun , Rose, Indigo V. L. , Kim, Hyosung , Xia, Wenlong , Romero-Fernandez, Wilber , Rooney, Brendan , Koontz, Mark , Li, Emmy , Ao, Yan , Wang, Shinong , Krawczyk, Mitchell , TCW, Julia , Goate, Alison , Zhang, Ye , Ullian, Erik M. , Sofroniew, Michael V. , Fancy, Stephen P. J. , Schrag, Matthew S. , Lippmann, Ethan S. and Kampmann, Martin
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Astrocytes become reactive in response to insults to the central nervous system by adopting context-specific cellular signatures and outputs, but a systematic understanding of the underlying molecular mechanisms is lacking. In this study, we developed CRISPR interference screening in human induced pluripotent stem cell-derived astrocytes coupled to...
Alternative Titles
Full title
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states
Authors, Artists and Contributors
Author / Creator
Rose, Indigo V. L.
Kim, Hyosung
Xia, Wenlong
Romero-Fernandez, Wilber
Rooney, Brendan
Koontz, Mark
Li, Emmy
Ao, Yan
Wang, Shinong
Krawczyk, Mitchell
TCW, Julia
Goate, Alison
Zhang, Ye
Ullian, Erik M.
Sofroniew, Michael V.
Fancy, Stephen P. J.
Schrag, Matthew S.
Lippmann, Ethan S.
Kampmann, Martin
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9633461
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9633461
Other Identifiers
ISSN
1097-6256,1546-1726
E-ISSN
1546-1726
DOI
10.1038/s41593-022-01180-9
