Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encod...
Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The viral delivery of base editors has been complicated by their size and by the limited packaging capacity of adeno-associated viruses (AAVs). Typically, dual-AAV approaches based on
trans
-splicing inteins have been used. Here we show that, compared with dual-AAV systems, AAVs with size-optimized genomes incorporating compact adenine base e...
Alternative Titles
Full title
Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9652153
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9652153
Other Identifiers
ISSN
2157-846X
E-ISSN
2157-846X
DOI
10.1038/s41551-022-00911-4
