Endocrine resistance and breast cancer plasticity are controlled by CoREST
Endocrine resistance and breast cancer plasticity are controlled by CoREST
About this item
Full title
Author / Creator
Garcia-Martinez, Liliana , Adams, Andrew M. , Chan, Ho Lam , Nakata, Yuichiro , Weich, Natalia , Stransky, Stephanie , Zhang, Zhao , Alshalalfa, Mohamed , Sarria, Leonor , Mahal, Brandon A. , Kesmodel, Susan B. , Celià-Terrassa, Toni , Liu, Zhijie , Minucci, Saverio , Bilbao, Daniel , Sidoli, Simone , Verdun, Ramiro E. and Morey, Lluis
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Resistance to cancer treatment remains a major clinical hurdle. Here, we demonstrate that the CoREST complex is a key determinant of endocrine resistance and ER
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breast cancer plasticity. In endocrine-sensitive cells, CoREST is recruited to regulatory regions co-bound to ERα and FOXA1 to regulate the estrogen pathway. In contrast, during te...
Alternative Titles
Full title
Endocrine resistance and breast cancer plasticity are controlled by CoREST
Authors, Artists and Contributors
Author / Creator
Adams, Andrew M.
Chan, Ho Lam
Nakata, Yuichiro
Weich, Natalia
Stransky, Stephanie
Zhang, Zhao
Alshalalfa, Mohamed
Sarria, Leonor
Mahal, Brandon A.
Kesmodel, Susan B.
Celià-Terrassa, Toni
Liu, Zhijie
Minucci, Saverio
Bilbao, Daniel
Sidoli, Simone
Verdun, Ramiro E.
Morey, Lluis
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9707522
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9707522
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-022-00856-x
