SARS-CoV-2 down-regulates ACE2 through lysosomal degradation
SARS-CoV-2 down-regulates ACE2 through lysosomal degradation
About this item
Full title
Author / Creator
Publisher
United States: The American Society for Cell Biology
Journal title
Language
English
Formats
Publication information
Publisher
United States: The American Society for Cell Biology
Subjects
More information
Scope and Contents
Contents
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes its Spike (S) glycoprotein to bind to the angiotensin-converting enzyme 2 (ACE2) receptor for cellular entry. ACE2 is a critical negative regulator of the renin-angiotensin system and plays a protective role in preventing tissue injury. Expression of ACE2 has been shown to decrea...
Alternative Titles
Full title
SARS-CoV-2 down-regulates ACE2 through lysosomal degradation
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9727799
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9727799
Other Identifiers
ISSN
1059-1524
E-ISSN
1939-4586
DOI
10.1091/mbc.E22-02-0045
