The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants
The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants
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Author / Creator
Rothenberger, Sylvia , Hurdiss, Daniel L. , Walser, Marcel , Malvezzi, Francesca , Mayor, Jennifer , Ryter, Sarah , Moreno, Hector , Liechti, Nicole , Bosshart, Andreas , Iss, Chloé , Calabro, Valérie , Cornelius, Andreas , Hospodarsch, Tanja , Neculcea, Alexandra , Looser, Thamar , Schlegel, Anja , Fontaine, Simon , Villemagne, Denis , Paladino, Maria , Schiegg, Dieter , Mangold, Susanne , Reichen, Christian , Radom, Filip , Kaufmann, Yvonne , Schaible, Doris , Schlegel, Iris , Zitt, Christof , Sigrist, Gabriel , Straumann, Marcel , Wolter, Julia , Comby, Marco , Sacarcelik, Feyza , Drulyte, Ieva , Lyoo, Heyrhyoung , Wang, Chunyan , Li, Wentao , Du, Wenjuan , Binz, H. Kaspar , Herrup, Rachel , Lusvarghi, Sabrina , Neerukonda, Sabari Nath , Vassell, Russell , Wang, Wei , Adler, Julia M. , Eschke, Kathrin , Nascimento, Mariana , Abdelgawad, Azza , Gruber, Achim D. , Bushe, Judith , Kershaw, Olivia , Knutson, Charles G. , Balavenkatraman, Kamal K. , Ramanathan, Krishnan , Wyler, Emanuel , Teixeira Alves, Luiz Gustavo , Lewis, Seth , Watson, Randall , Haeuptle, Micha A. , Zürcher, Alexander , Dawson, Keith M. , Steiner, Daniel , Weiss, Carol D. , Amstutz, Patrick , van Kuppeveld, Frank J. M. , Stumpp, Michael T. , Bosch, Berend-Jan , Engler, Olivier and Trimpert, Jakob
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with potential resistance to existing drugs emphasizes the need for new therapeutic modalities with broad variant activity. Here we show that ensovibep, a trispecific DARPin (designed ankyrin repeat protein) clinical candidate, can engage the three units of the s...
Alternative Titles
Full title
The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants
Authors, Artists and Contributors
Author / Creator
Hurdiss, Daniel L.
Walser, Marcel
Malvezzi, Francesca
Mayor, Jennifer
Ryter, Sarah
Moreno, Hector
Liechti, Nicole
Bosshart, Andreas
Iss, Chloé
Calabro, Valérie
Cornelius, Andreas
Hospodarsch, Tanja
Neculcea, Alexandra
Looser, Thamar
Schlegel, Anja
Fontaine, Simon
Villemagne, Denis
Paladino, Maria
Schiegg, Dieter
Mangold, Susanne
Reichen, Christian
Radom, Filip
Kaufmann, Yvonne
Schaible, Doris
Schlegel, Iris
Zitt, Christof
Sigrist, Gabriel
Straumann, Marcel
Wolter, Julia
Comby, Marco
Sacarcelik, Feyza
Drulyte, Ieva
Lyoo, Heyrhyoung
Wang, Chunyan
Li, Wentao
Du, Wenjuan
Binz, H. Kaspar
Herrup, Rachel
Lusvarghi, Sabrina
Neerukonda, Sabari Nath
Vassell, Russell
Wang, Wei
Adler, Julia M.
Eschke, Kathrin
Nascimento, Mariana
Abdelgawad, Azza
Gruber, Achim D.
Bushe, Judith
Kershaw, Olivia
Knutson, Charles G.
Balavenkatraman, Kamal K.
Ramanathan, Krishnan
Wyler, Emanuel
Teixeira Alves, Luiz Gustavo
Lewis, Seth
Watson, Randall
Haeuptle, Micha A.
Zürcher, Alexander
Dawson, Keith M.
Steiner, Daniel
Weiss, Carol D.
Amstutz, Patrick
van Kuppeveld, Frank J. M.
Stumpp, Michael T.
Bosch, Berend-Jan
Engler, Olivier
Trimpert, Jakob
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9750863
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9750863
Other Identifiers
ISSN
1087-0156,1546-1696
E-ISSN
1546-1696
DOI
10.1038/s41587-022-01382-3
