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CD8+ T cell differentiation and dysfunction in cancer

CD8+ T cell differentiation and dysfunction in cancer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9792152

CD8+ T cell differentiation and dysfunction in cancer

About this item

Full title

CD8+ T cell differentiation and dysfunction in cancer

Publisher

London: Nature Publishing Group UK

Journal title

Nature reviews. Immunology, 2022-04, Vol.22 (4), p.209-223

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

CD8
+
T cells specific for cancer cells are detected within tumours. However, despite their presence, tumours progress. The clinical success of immune checkpoint blockade and adoptive T cell therapy demonstrates the potential of CD8
+
T cells to mediate antitumour responses; however, most patients with cancer fail to achieve long-term r...

Alternative Titles

Full title

CD8+ T cell differentiation and dysfunction in cancer

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9792152

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9792152

Other Identifiers

ISSN

1474-1733

E-ISSN

1474-1741

DOI

10.1038/s41577-021-00574-3

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