Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures
Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Fragment based methods are now widely used to identify starting points in drug discovery and generation of tools for chemical biology. A significant challenge is optimization of these weak binding fragments to hit and lead compounds. We have developed an approach where individual reaction mixtures of analogues of hits can be evaluated without purif...
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Full title
Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9814918
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9814918
Other Identifiers
ISSN
2399-3669
E-ISSN
2399-3669
DOI
10.1038/s42004-020-00367-0
