Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin...
Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension
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Publisher
England: Oxford University Press
Journal title
Language
English
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Publisher
England: Oxford University Press
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Scope and Contents
Contents
The presence of senescent cells within tissues has been functionally linked to malignant transformations. Here, using tension-gauge tethers technology, particle-tracking microrheology, and quantitative microscopy, we demonstrate that senescent-associated secretory phenotype (SASP) derived from senescent fibroblasts impose nuclear lobulations and vo...
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Full title
Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9830950
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9830950
Other Identifiers
ISSN
2752-6542
E-ISSN
2752-6542
DOI
10.1093/pnasnexus/pgac270
