Habenular TCF7L2 links nicotine addiction to diabetes
Habenular TCF7L2 links nicotine addiction to diabetes
About this item
Full title
Author / Creator
Duncan, Alexander , Heyer, Mary P. , Ishikawa, Masago , Caligiuri, Stephanie P. B. , Liu, Xin-an , Chen, Zuxin , Micioni Di Bonaventura, Maria Vittoria , Elayouby, Karim S. , Ables, Jessica L. , Howe, William M. , Bali, Purva , Fillinger, Clementine , Williams, Maya , O’Connor, Richard M. , Wang, Zichen , Lu, Qun , Kamenecka, Theodore M. , Ma’ayan, Avi , O’Neill, Heidi C. , Ibanez-Tallon, Ines , Geurts, Aron M. and Kenny, Paul J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Diabetes is far more prevalent in smokers than non-smokers, but the underlying mechanisms of vulnerability are unknown. Here we show that the diabetes-associated gene
Tcf7l2
is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors. Inhibition of TCF7L2 s...
Alternative Titles
Full title
Habenular TCF7L2 links nicotine addiction to diabetes
Authors, Artists and Contributors
Author / Creator
Heyer, Mary P.
Ishikawa, Masago
Caligiuri, Stephanie P. B.
Liu, Xin-an
Chen, Zuxin
Micioni Di Bonaventura, Maria Vittoria
Elayouby, Karim S.
Ables, Jessica L.
Howe, William M.
Bali, Purva
Fillinger, Clementine
Williams, Maya
O’Connor, Richard M.
Wang, Zichen
Lu, Qun
Kamenecka, Theodore M.
Ma’ayan, Avi
O’Neill, Heidi C.
Ibanez-Tallon, Ines
Geurts, Aron M.
Kenny, Paul J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9851388
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9851388
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1653-x
